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Ribosome profiling of the RISC complex provides valuable insights into the translation dynamics and mechanisms of gene regulation mediated by RNA interference. The RNA-induced silencing complex (RISC) plays a crucial role in post-transcriptional regulation by binding to small RNAs, such as microRNAs, and targeting complementary messenger RNAs for degradation or translational repression. By applying ribosome profiling to study the RISC complex, researchers can pinpoint the precise locations where the RISC complex interacts with target mRNAs during translation, revealing how specific RISC complex targets are regulated. This method allows for a deeper understanding of the molecular interactions that govern gene silencing and contributes to the development of novel therapeutic approaches targeting the RISC complex and its associated pathways in diseases like cancer and viral infections.
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Category
Research -
Created
Friday, 14 February 2025 -
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Gemini Smith
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