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The ovalbumin-induced asthma model is a widely used experimental system for studying allergic asthma and evaluating potential therapeutic interventions. In this model, ovalbumin (OVA), a protein commonly found in egg whites, is used to sensitize and challenge mice or other animals, triggering an allergic response similar to human asthma. The immune system of the animals reacts to the ovalbumin exposure, leading to the development of airway inflammation, mucus production, and bronchoconstriction—key features of asthma. This model allows researchers to investigate the underlying mechanisms of asthma, including the roles of immune cells such as T-helper 2 (Th2) cells, eosinophils, and IgE antibodies. It also provides a platform for testing new treatments, such as corticosteroids, biologics, or small molecule inhibitors, that can potentially reduce airway inflammation and improve lung function. The ovalbumin-induced asthma model remains a valuable tool for advancing our understanding of asthma pathophysiology and developing more effective asthma therapies.
